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111 The only acceptable alternative endpoint in drug development, histological evidence, consists of the resolution of steatohepatitis and no worsening of liver fibrosis, or improvement in liver fibrosis of at least one stage without worsening of steatohepatitis

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It is produced naturally by the liver and involved in many processes in the body, mainly detoxification but also plays a role in tissue building and repair, making chemicals and proteins, and for immune system support